Albumin Dose Calculator
Post-paracentesis replacement · builds every field of the Epic order.
1 · Product and paracentesis details
More use cases (general albumin replacement, hypoalbuminemia) will be added in a later version.
25 percent is the standard concentrated product for large volume paracentesis because it delivers the same grams in less infused volume.
Dose recommendation & coverage
2 · Epic order for albumin human 25% (bottle 25 g)
3 · Order summary
Dosing logic and references
Abbreviations. LVP is large volume paracentesis. PPCD is post paracentesis circulatory dysfunction. ACLF is acute on chronic liver failure. IV is intravenous. AASLD is the American Association for the Study of Liver Diseases. AGA is the American Gastroenterological Association. FDA is the United States Food and Drug Administration. NEJM is the New England Journal of Medicine.
When to give it. Albumin is recommended when more than 5 L of ascites are removed. For 5 L or less it is generally not required, unless the patient has ACLF, in which case give albumin regardless of the volume removed.
How much. The dose is 6 to 8 g of albumin for every liter removed. This tool uses 8 g per liter, which matches the FDA label for 25 percent albumin (8 g per 1,000 mL of ascites removed). The total is rounded to the nearest whole 25 g bottle.
Volume and rate. A 25 g bottle of 25 percent albumin holds 100 mL, and a 25 g bottle of 5 percent holds 500 mL. Rate in mL per hour equals the volume in mL divided by the duration in hours.
Caution. The risk of PPCD goes up when more than 8 L is removed in a single session.
Sources. AASLD 2021 Practice Guidance (Biggins and colleagues, Hepatology). AGA 2024 Clinical Practice Update (Garcia-Tsao and colleagues, Gastroenterology). Ge and Runyon, NEJM 2016. FDA Albuminex label, 2024.
This is a clinical decision support tool for licensed clinicians. Check every dose, rate, and duration against your institutional protocol and the patient's clinical context before ordering. It does not replace clinical judgment.